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Genetics
delay ripening, control post-harvest loss
June 14
Times of India
NEW DELHI -- Scientists have isolated a gene part,
called promoter, from tomato plant and hope to use it in
modified form for delaying fruit ripening by a technology
that can be extended to several other perishable fruits
and vegetables.
The country does not have proper cold storage and refrigerated
transport facilities which causes wastage of almost twenty
per cent of all perishable fruit and vegetables due to
rotting, Dr Kailash Bansal, principal scientist at Indian
Agriculture Research Institute (IARI), the institute which
accomplished the task, told PTI.
Elaborating on the new technique called the antisense
RNA technology, he said, in it the pathway by which a
fruit ripening hormone called ethylene is produced by
plants, is blocked.
"For this, we have recently isolated a promoter
which is needed for functioning of the gene that produces
an enzyme called ACC synthase. This enzyme is required in
an important step for ethylene synthesis," he said.
The ACC synthase producing gene was isolated about two
years ago.
The antisense RNA technology involves introduction of
the gene and its promoter in reverse form in tomato plant
cells. The product of reverse gene blocks the product of
the normal gene, thus preventing production of ACC
synthase enzyme.
This genetic technology would help in reducing post
harvest losses and boost exports by giving the plants an
inherent capacity to delay ripening, Bansal said, adding
though non-genetic methods are in use to delay ripening,
these are not feasible on large scale.
However, not all the products of normal gene are
blocked and some amount of enzyme is still produced, he
said. But, as ethylene is not produced in sufficient
quantity, ripening does not take place at normal rate and
is slowed down, Bansal said.
A similar method is being tested in US, where
scientists are using the gene promoter from their
indigenous plants, he said, adding in that method,
ethylene needs to be supplied exogenously.
"In India, we are trying to regulate ethylene
synthesis so that ripening is slowed down but exogenous
ethylene is not needed," he said. Earlier, Indian
scientists had been working with an imported promoter,
"but under the WTO it is better that we have our own
promoter for commercializing."
"So far we have succeeded in introducing the gene
and its promoter in reverse form in tomato seedlings.
Molecular analysis and testing is on to analyze the status
of the transformed plants," he said, adding it would
take less than two years to transfer the technology to
field trials.
One problem is that as gene is introduced using a
bacterium (agrobacterium), a bacterial gene responsible
for antibiotic resistance is also transferred in plant
cells, he said.
Though, this gene does not have any effect on humans,
efforts are on to find some other bacterial marker, he
said. The technology has an advantage over the methods
like early plucking as tomato fruits do not ripen at the
same time and need plucking three-four times a year.
The new technology, which can be extended to mangoes
and bananas, would be more economical and give plants
uniformity in terms of ripening. It would also enhance
their nutrient content.
Genetically
engineered corn cleared in 17 food reactions
Product did not trigger
allergies, health officials report
June 14
Washington Post
Genetically engineered StarLink corn did not cause
allergic reactions in 17 people who had reported sometimes
severe reactions after eating corn tacos and tortillas
last fall, federal health officials said yesterday.
Blood tests failed to find any signs of antibodies to
the protein in the genetically engineered corn, indicating
none of those tested had experienced an allergic reaction,
the federal Centers for Disease Control and Prevention
said. All had complained to federal agencies last year of
reactions ranging from rashes to anaphylactic shock after
eating products made of yellow corn that might have
contained StarLink.
The results were applauded by advocates of
biotechnology as confirming the safety of StarLink in
particular and modified crops in general. But
environmental groups called the federal effort limited and
insufficient to answer the question of whether StarLink
can cause dangerous allergic reactions.
Carol Rubin, an epidemiologist with the CDC's National
Center for Environmental Health, said that while the test
results were "only a first step" in answering
questions about the safety of the corn, "it can be
seen as good news for consumers."
"Based on the test methods used, it is highly
unlikely that the people had an allergic reaction to"
StarLink, she said. "They may have experienced
allergic reactions to some food, but not the protein that
was tested."
But one of the people who suffered anaphylactic shock
after eating an enchilada made of yellow corn, Californian
Grace Booth, said she was still convinced she had a
reaction to StarLink.
"Everything else I ate in the 72 hours before I
got so sick, I've eaten again with no problem," she
said. "Frankly, I don't trust the tests."
StarLink is a variety of corn engineered to contain a
protein, called Cry9c, that can protect crops against
several insects. While many similar modified corns have
been approved for general use, StarLink was approved only
for animal feed because of concerns that it broke down
more slowly than many proteins and might cause allergic
reactions. The corn nonetheless inadvertently entered the
human food supply, triggering the recall of about 300 corn
products.
The developer of the corn, Aventis CropSciences of
Research Triangle, N.C., has asked the Environmental
Protection Agency for retroactive approval to allow small
amounts of StarLink corn in food for people. The tests
results announced yesterday were requested by a scientific
advisory panel convened by the EPA to help determine
whether to issue that approval. The advisory panel is set
to meet again on the StarLink issue next month.
Val Giddings of the Biotechnology Industry Organization
said that yesterday's results meant that the case was
"slam-dunk closed."
"We are pleased, but not the least bit surprised,
that the data released by the CDC today is consistent with
the vast body of data we have had all along showing the
safety of StarLink corn," he said. "If the
protein was allergenic, they would not have found these
negative reactions."
The tests were done at a Food and Drug Administration
laboratory, and required new research into how to test for
possible reactions to foods containing genetically
modified crops. The blood samples, which included some
taken before StarLink was developed and some from highly
allergic people, were sent with number codes to prevent
bias.
Rebecca Goldburg, a scientist with Environmental
Defense, said that the CDC sample was too small to be
meaningful, and that the EPA should not approve StarLink
for human use based on the results. She said a wider test
of people, especially children and those who eat enough
yellow corn products to develop a sensitivity, is needed.
"The results are comforting, but hardly
definitive," she said. "This is not something
that could be published in a scientific journal and be
accepted as conclusive. They didn't target the right
people to test."
Mark Helm of Friends of the Earth, an environmental
group that first brought the issue of StarLink in taco
shells to public attention, said it was "borderline
irresponsible to say this stuff is safe. It still has not
been rigorously tested."
According to the CDC's Rubin, 51 people had reported
experiencing adverse reactions in the weeks after StarLink
was found in tacos and other corn products.
Of those, she said, 28 fit the definition of having
suffered a food allergy, and 17 of them agreed to provide
a blood sample. Some of the reactions had been quite
severe, and Rubin said that all will receive reports on
what the researchers learned about their blood.
Allergy experts generally agree that if antibodies to
StarLink had been found in the blood of the 17, that still
would not have meant the people had allergic reactions to
the modified corn. That determination could be made only
after completing skin prick tests or food challenges.
Booth, 35, who works at a youth center, said that she
remained willing to have a skin test with StarLink protein
or even eat something made with StarLink under a doctor's
supervision. "I still feel like I haven't gotten to
the bottom of this, and very much want to do that,"
she said.
U.S.
finds no allergies to altered corn
June 14
New York Times
Government scientists said yesterday that they had
found no evidence that any people had had allergic
reactions to the genetically modified StarLink corn.
The findings could dispel public concern that the corn,
which spread through the nation's food supply even though
it was never approved for human consumption, represents a
threat to public health.
The results, announced by the Centers for Disease
Control and Prevention, could also clear the way for the
Environmental Protection Agency to permit small amounts of
the corn to be present in food without leading to recalls,
something that would greatly relieve the farmers, grain
processors and food companies.
The C.D.C. and the Food and Drug Administration tested
the blood of 17 people who had reported suffering allergic
reactions ranging from upset stomachs to potentially fatal
anaphylactic shock after eating products they thought
contained StarLink corn.
The agencies looked to see if the blood contained
antibodies to the protein in the corn that was considered
the possible allergen. No such antibodies were found, an
indication that none of the people had had immune
reactions to the corn protein.
"We do not have any positive results
whatsoever," said Carol S. Rubin, a research
scientist at the National Center for Environmental Health
at the C.D.C. Still, the report prepared by the centers
says that there is some possibility that people could be
allergic without having antibodies in their blood.
StarLink contains a bacterial gene that permits the
corn to produce a protein that kills the corn borer, a
major pest. But that protein, known as Cry9C, has some
characteristics of an allergen, mainly that it is not
digested easily in the stomach.
Because of those concerns, the corn was approved for
use as animal feed but not for human consumption. But it
leaked into the human food supply, causing huge recalls of
taco shells and other products, hurting American grain
exports, forcing grain elevators and food companies to
test incoming shipments of corn, and raising new concerns
about the possible health effects of genetically
engineered foods.
Now, the biotechnology industry, which said all along
that there was little threat to public health from the
corn, may breathe a bit easier. "We are pleased, but
not the slightest bit surprised," said L. Val
Giddings, vice president for food and agriculture of the
Biotechnology Industry Organization, a trade group.
Critics of genetically modified food said the testing
was insufficient. "These tests are not proof that
StarLink corn is safe for human consumption," said
Matt Rand, a spokesman for Genetically Engineered Food
Alert, a coalition of environmental groups. "This is
not a thorough investigation."
He said the government did not test the hundreds of
people who complained to food companies about reactions
instead of to the F.D.A. He also said it appeared that the
test might have been performed using Cry9C made by
bacteria, which might be different from the protein made
in the corn.
Dr. Rubin said she could not comment on the specifics
of the antibody test because it was designed by the F.D.A.
An F.D.A. spokeswoman said her agency would not comment.
Dr. Marc E. Rothenberg, the section chief for allergy
and immunology at Children's Hospital in Cincinnati and an
adviser to the E.P.A. on this issue, said that antibody
tests were more likely to report false positives than
false negatives. Just because a person has antibodies to a
protein does not mean she suffered an allergic reaction,
he said. But if there are no antibodies, he said, there is
only a tiny chance that the person had an allergic
reaction.
The results of the blood tests will be used by the
E.P.A. to decide whether to permit small amounts of
StarLink in human food. Aventis CropScience, the
company that developed StarLink, has asked the agency to
permit such a small presence for four years, so the food
industry would be spared the costs and disruptions of
testing and food recalls. The E.P.A. has scheduled a
meeting of its scientific advisory panel for next month to
discuss the issues.
Aventis
, which declined to comment on the results announced
yesterday, has asserted that since most of the StarLink
grown has been collected by the company and the
government, there is so little in the food supply that it
would not cause any public health problems even if Cry9C
were found to be an allergen.
The C.D.C. and the F.D.A. reviewed the cases of 51
people who had told the agency about allergic reactions
they thought were connected to StarLink. Of those, 28
people were considered to have had some sort of allergic
reaction, while the rest were judged to have had some
other health problem.
U.S.
finds no link in biotech corn, illness
June 14
Boston Globe
Tests carried out by the Food and Drug Administration
and the Centers for Disease Control have cast doubt on
claims by dozens of people that they became sick after
eating a genetically engineered corn not approved for
human consumption.
The results, released yesterday, found no evidence that
sensitivity to a protein known as Cry9c contained in
StarLink corn caused allergic reactions, which reportedly
ranged from itching to shock, the CDC said in the highly
anticipated report.
Although not definitive, the government's findings were
hailed by the biotechnology industry and could mark a
first step in ending the controversy that erupted when
StarLink was first discovered in a sample of Taco Bell
taco shells last year. Its presence prompted more than 300
recalls of everything from chips to corn dogs, slowed
grain exports, particularly to Asia, and threw part of the
country's agricultural industry into chaos.
Aventis SA, the French pharmaceutical company that
invented the variety and had earlier complained that the
government's tests would not be conclusive, declined to
comment on the results. But the Biotechnology Industry
Organization, a trade group in Washington, said the
findings should be enough ''to put concerns to rest.''
''As a scientist, there are always questions I'd like
to ask,'' said L. Val Giddings, the group's vice president
for food and agriculture. ''But from a standpoint of what
we need to know from a public health point of view, this
should be case-closed.''
Critics of the biotech industry said they thought the
study was far too limited. They contended that more people
should have undergone tests and that the government's
scientists should have employed better methods, including
skin-prick tests.
''This test does not prove that StarLink corn is safe
for human consumption,'' said Matt Rand, campaign manager
for biotech at the National Environment Trust, a lobbying
group that opposes bioengineered foods. ''They chose only
to test a handful of people. This is not a representative
sample of the population that was exposed to StarLink
corn.''
The danger posed by StarLink, which the government had
approved only for animal consumption, has been a matter of
fierce debate.
More than 50 people had reported allergic reactions -
diarrhea, vomiting, stomach aches, and shock - after
eating products that contained the corn.
Critics also have cited a report by a panel of
independent scientists in December to the Environmental
Protection Agency. The report said that StarLink shows a
''medium likelihood'' of causing an allergic reaction in
some people. That same report, however, said the low
levels of the protein likely present in food probably
would not make people sick.
CDC officials stopped short of calling yesterday's
results the final word. Even the report acknowledged that
the tests on blood samples, which did not detect
antibodies identifying an allergy, could not rule out the
possibility of a reaction.
''It was a first safe step,'' said Dr. Carol Rubin, an
epidemiologist with the CDC's Center for Environmental
Health.
The results were eagerly anticipated because the EPA is
considering a request by Aventis to allow a trace amount
of StarLink in foods for humans. The EPA said yesterday
that while the results were important, it would make no
decision on Aventis' request until after a July 17-18
meeting of its scientific advisory panel.
U.S. watchdog
group assails genetic field testing
June 14
Reuters
Boston -- A consumer watchdog group on Thursday accused
the U.S. Department of Agriculture (USDA) of rubber
stamping approval of field tests of genetically engineered
crops that could harm people and the environment.
``Our environment is serving as the laboratory for
widespread experimentation of genetically engineered
organisms with profound risks that, once released, can
never be recalled,'' the U.S. Public Interest Research
Group said in a 98-page report called ``Raising Risk.''
The Washington-based group said the USDA authorized
nearly 29,000 field tests of genetically engineered
organisms through 2000. The agency only has rejected 4
percent of the applications to conduct field tests, the
report stated.
The experiments were being done in an open environment
with little oversight or public notification, the watchdog
group said. Introducing nonnative organisms into the
environment is estimated to cost the United States $123
billion annually in ecosystem damage, it added.
``Contrary to popular belief, the technology is not
very precise,'' the report said. ``Scientists cannot
control the location where the gene is inserted into the host's
genetic code, nor guarantee stable expression of the gene
in the new genetically engineered organism.''
The experiments sometime deal with bizarre
combinations, such as introducing tomato genes to fish
genes, or even combining pig genes with human genes,
according to the report.
Between 1987 and 2000, leading U.S. biotech firm
Monsanto Co. applied to conduct the most field tests every
year.
Hawaii has hosted the most field tests with 3,275 and
Illinois ranked second with 2,832, according to the study.
Concerns about genetically modified food reached a
frenzy in the United States last year when StarLink, a
genetically modified corn which has been approved for
animal feed but not for human consumption, was discovered
in a number of food products. StarLink is made by the
Franco-German pharmaceutical group Aventis .
A report from the U.S. Centers for Disease Control and
Prevention released on Wednesday found the biotech corn
that spawned a nationwide recall last fall did not cause
the allergic reactions that people reported after finding
out about the grain.
U.S. PIRG recommends a moratorium on field testing and
commercialization of genetically engineered foods and
crops until it can be determined they do no harm the
environment or people.
The demand for testing genetically modified plants
surged in the 1980s during the U.S. biotech boom.
The U.S. PIRG report says corporations and universities
are becoming increasingly secretive about their genetic
testing. From 1989 to 1999, the percentage of crops
containing genes declared confidential increased nearly
every year. Last year, 65 percent of the genetically
engineered crops were declared ``confidential business
information,'' the study said.
Feature:
Argentine farmers bet on biotech
June 14
Reuters
Buenos Aires -- Genetically modified (GM) soybean seeds
have made Argentine farmer Hector Salmoiraghi's life a lot
easier, he says as he stoops to examine a soybean plant in
a vast field lined with eucalyptus trees.
Salmoiraghi, whose father and grandfather were also
farmers, has been growing soybeans for 25 years, outside
the port city of San Pedro, some 124 miles (200 km)
northwest of Buenos Aires.
``Genetically-modified soy simplified everything,'' he
said, adjusting his black gaucho-style beret and standing
tall in his rubber boots and Wrangler jeans.
Salmoiraghi began using U.S.-based biotechnology giant
Monsanto's Roundup Ready (RR) soybean seeds five years
ago.
Made to be resistant to the company's powerful Roundup
weed killer, the seeds cut costs by an estimated $50-$60
per hectare (2.47 acres) by reducing the preparation
needed before planting.
Salmoiraghi, who planted 250 hectares (617.5 acres)
with GM soy this season and plans to plant more next year,
says he'd never go back to the traditional seeds: ``It
wouldn't make sense. GM soy is much easier to work with.''
He is one of thousands of Argentine farmers singing the
praises of GM products, and now the government is behind
them more than ever before.
Argentina, a major grain and oilseed producer, is
second only to the United States in the use of
biotechnology products and has recently re-dedicated
itself to promoting their development and attracting
biotech companies that want to invest here.
After 3 years of a de facto moratorium on approving GM
products, Argentina in May authorized the use of
Monsanto's RR cotton.
Weeks later, the government created a biotechnology
commission and Agriculture Secretary Marcelo Regunaga set
off for the United States, where he met with biotech
companies and visited research centers.
``We share the biotechnology policy of the U.S.,'' said
Regunaga in a recent interview.
``I told (U.S. Agriculture) Secretary (Ann) Veneman
that in all the international forums, we need to present a
common position in which Argentina would have a more
aggressive attitude than it has had in the past.''
Argentina is betting that biotechnology is the wave of
the future. But sharing a common policy with the United
States also means the countries could share common foes.
ANTI-GM GROUPS
While proponents say GM products increase efficiency,
environmental and consumer groups say the products are not
well regulated and could contain hidden health and
environmental risks.
``We are against the sale of these products until there
is conclusive evidence of the long-term effects they could
have,'' said Karla Irigoyen, the Chile-based
representative of watchdog group Consumers International.
``There is a lot of concern about the use of GM
products in Argentina, not only for the sake of Argentine
consumers but also for consumers in all of Latin
America,'' where Argentina sends exports, said Irigoyen.
The government is well aware that GM products are
controversial and will step up measures to ensure that no
unapproved products are used illegally and that approved
products are safe, said Regunaga.
Also approved in Argentina are insect-tolerant corns
made by Swiss company Novartis and Monsanto, a
herbicide-tolerant corn made by Franco-German company
Aventis and an insect-tolerant cotton made by Monsanto.
THE TRADE ISSUE
Argentina's renewed commitment to biotechnology means
that GM products are here to stay, at least for the time
being. But whether GM is the future will depend on the
impact the use of these products has on trade.
Agricultural shipments make up about 60 percent of
Argentina's exports and GM products are a particularly
dicey topic in the European Union and Asia, where imports
of some products have been restricted on concern they may
not be safe for human consumption.
``By approving (GM products) Argentina is definitely
moving in the wrong direction and is risking its
exports,'' said Emiliano Ezcurra, the coordinator of the
biodiversity campaign for the Buenos Aires office of
global environmental group Greenpeace.
Argentina sent nearly 30 percent of its grain exports
and about 60 percent of its vegetable oil exports to Asia
in 2000, according to data from the Agriculture
Department.
China last week ruled that all production and sales of
GM foods, including imports, must have government approval
certifying that they do not cause any harm to humans,
animals or the environment. It remains to be seen how the
move will affect Argentine exports.
The European Union, where Argentina shipped about 10
percent of its grain exports and 60 percent of grain
byproducts in 2000, has not approved any new GM crop
varieties since 1998.
The European Parliament in February approved strict
rules to regulate GM organisms, but France and five other
countries said they would continue to block new GM permits
until further rules are put in place ensuring gene-altered
products can be traced back to their source.
``In Europe, it's a question of time,'' Carlos Popik,
president of the Argentine unit of Monsanto, told Reuters
in a recent interview.
``The question is purely political,'' he said. ``Europe
prefers to increase production by subsidizing it instead
of making it more efficient. These are the types of things
that will be changed by time.''
Regunaga seemed unconcerned about Europe: ``In Europe
there are people in favor of and people against''
biotechnology, he said. ``Certainly, we are going to try
to find our friends in Europe so that we can have a more
aggressive international position in favor of
biotechnology.''
Politics aside, Argentine farmers will likely continue
to support development of GM products that cut costs.
Salmoiraghi says RR soy has helped farmers survive in
San Pedro, as lower global commodity prices, high interest
rates and fuel prices and tax pressure have sent many
small producers packing.
``GM soy has helped us,'' he said. ``It hasn't helped
as much as it could have because prices have fallen, but
it has certainly helped because with these fuel prices,
I'd say that even we medium-sized producers wouldn't be
around anymore.''
Organic
food booms in Italy but sales still modest
June 14
Reuters
ROME -- Demand for organic food is exploding in Italy,
but a hard core of consumers remains to be persuaded--with
one in four Italians still unaware of what it is, Italy's
biggest farmers' group said on Thursday.
Italian shoppers, proud of their country's culinary
tradition and its renowned pasta, ham, cheese and wine,
are increasingly turning to organic olive oil, rice, fruit
and vegetables.
Research by Coldiretti showed the Italian market for
organic food was growing by 20% a year and accounted for
0.6% of total food sales in 2000. Total organic food sales
in Italy were 1.5 trillion lire ($660.6 million) in 2000.
Demand for organic produce is growing sharply across
western Europe as consumers, worried about food scares and
genetically modified foods, seek guarantees of food
safety.
According to a recent survey by the farm ministry, most
Italians oppose genetic engineering of their foods because
of health worries.
``Demand for organic food is exploding, but one Italian
in four does not know what it is,'' Coldiretti said on its
web site.
The typical profile of a consumer of organic food in
Italy was a single male graduate living in the wealthy
north of the country, aged between 40 and 49, who had a
well-paid job, Coldiretti said.
Many Italian supermarkets have special sections
reserved for organic fare, which costs more than
conventional foods.
``The survey of a representative sample of the entire
Italian population reveals a worrying lack of awareness
and information about organic produce due in part to
unclear and incomprehensible labeling,'' Coldiretti said.
Coldiretti's president Paolo Bedoni urged strict
standards for labeling of organic foods so that consumers
were correctly informed about produce.
``It is necessary to implement measures to protect
consumers and farmers from products entering the market
that do not have the necessary guarantees,'' he said.
The Coldiretti research echoes the results of a recent
poll by farm research body ISMEA, which said Italian
shoppers, influenced by food scares, were increasingly
turning to organic foods but that their awareness of such
produce was patchy.
According to the poll of supermarkets and hypermarkets,
65% said Italian demand for organic foods was growing
while 67% said consumers were poorly informed about it.
Italy is the ``most organic'' country in the EU,
according to Coldiretti, with almost 50,000 companies
engaged in producing organic food-40% of the EU total--and
an organic farm area of almost one million hectares.
This represents more than a quarter of the total EU
organic farm area.
Organic cereals--mainly durum wheat for pasta making,
followed by barley, soft wheat and rice--represent between
23 and 25% of total organic agricultural production in
Italy, according to Coldiretti.
Production of organically grown cereals is mainly in
northern and central Italy. Farming of organic fruits and
vegetables is predominantly in the south.
Analysts expect the new center-right government of
Silvio Berlusconi, sworn into office this week, to
encourage organic farming in Italy, which has an ideal
climate for growing many types of organic produce.
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